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KMID : 0613820070170121654
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Journal of Life Science
2007 Volume.17 No. 12 p.1654 ~ p.1659
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Effects of Single Total Body Irradiation (TBI) on the Peripheral Blood of Piglets
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Lee Jae-Hoon
Kang Eun-Hee
Chung Da-Jung
Kim Dong-Ku
Kim Jae-Hwan
Shin Hyun-Soo
Ahn Jung-Yong
Park Jin-Ki
Chang Won-Kyong
Choi Che-Bong
Kim Hwi-Yool
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Abstract
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We examined total body irradiation (TBI)-induced effects by complete blood count (CBC) and fluorescence-activated cell sorter analysis (FACS) in the piglet following radiation irritation. A CBC included red blood cell count, white blood cell count, and platelet cell count. Four piglets were examined in this study and each piglet was divided by irradiation dose, two piglets with 4 Gy, two with 6 Gy, one with 8 Gy. All piglets showed leukopenia, thrombocytopenia after irradiation. In 6 and 8 Gy group, three piglets showed severe hemostatic disorder and gastrointestinal disorder suchas diarrhea and anorexia, and they died between 10 and 15 days after radiation irritation. In 4 Gy, two piglets showed no clinical sign after radiation injury, but persistent leukopenia was shown in blood examination. We suggest that a single TBI dose less than 6 Gy is adequate for conditioning piglet for bone marrow transplantation.
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KEYWORD
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Total body irradiation, immunosuppression, FACS, piglets
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